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首页> 外文OA文献 >Transcriptome profiles of metamorphosis in the ornamented pygmy frog Microhyla fissipes clarify the functions of thyroid hormone receptors in metamorphosis
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Transcriptome profiles of metamorphosis in the ornamented pygmy frog Microhyla fissipes clarify the functions of thyroid hormone receptors in metamorphosis

机译：装饰的侏儒青蛙小舌苔裂的蜕变的转录组谱阐明了甲状腺激素受体在蜕变中的功能

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Anuran metamorphosis is an excellent system in which to study postembryonic development. Studies on Xenopus (Mesobatrachia) show that thyroid hormone receptors (TRs) regulate metamorphosis in a ligand-dependent manner by coordinating the action of hundreds of genes. However, whether this mechanism is conserved among amphibians is still unknown. To understand the molecular mechanism of this universal phenomenon, we report the transcriptional profiles of the three key developmental stages in Microhyla fissipes (Neobatrachia): premetamorphosis (PM), metamorphic climax (MC) and completion of metamorphosis (CM). In total, 2,293 differentially expressed genes were identified from comparisons of transcriptomes, and these genes showed stage-specific expression patterns. Unexpectedly, we found that TRa was highly expressed in Xenopus laevis and Bufo gargarizans at premetamorphosis but showed low expression in M. fissipes. In contrast, TR beta was highly expressed during metamorphosis in M. fissipes and X. laevis. This result may imply that TR beta is essential for initiating metamorphosis, at least in M. fissipes. Thus, our work not only identifies genes that are likely to be involved in Neobatrachia metamorphosis but also clarifies the roles of unliganded TRa in regulating tadpole growth and timing of metamorphosis, which may be conserved in anurans, and the role of liganded TR beta in launching metamorphosis.
机译：无核变态是研究胚胎后发育的极好系统。爪蟾（Mesobatrachia）的研究表明，甲状腺激素受体（TRs）通过协调数百种基因的作用，以配体依赖性方式调节变态。但是，尚不清楚这种机制在两栖动物中是否保守。为了了解这种普遍现象的分子机制，我们报道了裂纹蝇（Neobatrachia）的三个关键发育阶段的转录概况：变态前期（PM），变质高潮（MC）和变态完成（CM）。从转录组的比较中总共鉴定出2293个差异表达基因，这些基因显示出阶段特异性表达模式。出乎意料的是，我们发现TRa在变形前期在非洲爪蟾和中华蟾蜍中高表达，但在裂殖藻中却低表达。相比之下，TRβ在小裂殖肌和X. laevis的变态过程中高度表达。该结果可能暗示TRβ对于至少在裂殖肌中启动变态是必不可少的。因此，我们的工作不仅鉴定了可能与新生细菌气管变态有关的基因，而且阐明了无配体的TRa在调节t生长和变态时机中的作用（在无核动物中可能是保守的），以及配体TRβ在发射中的作用。变态。

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